Development of PD3 and PD3-B for PDEδ inhibition to modulate KRAS activity-Reference-Cited by-同舟云学术

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Development of PD3 and PD3-B for PDEδ inhibition to modulate KRAS activity

Published:2022-06-13 Issue:1 Volume:37 Page:1656-1666
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Lee Jungeun¹,Lee Ho Jin¹,Lee Yeongcheol¹,Lim Bumhee¹,Gam Jongsik²,Oh Dong-Chan³,Lee Jeeyeon¹

Affiliation:

1. College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea

2. Department of Medicinal Bioscience, College of Interdisciplinary & Creative Studies, Konyang University, Nonsan, Republic of Korea

3. Natural Products Research Institute, College of Pharmacy, Seoul National University, Seoul, Republic of Korea

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2022.2086865

Reference37 articles.

1. Drugging the undruggable RAS: Mission Possible?

2. RAS isoforms and mutations in cancer at a glance

3. Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

4. The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants

5. Drugging RAS: Know the enemy

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