New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization

Author:

Mohammed Hamada H. H.12,Abd El-Hafeez Amer Ali34,Ebeid Kareem567,Mekkawy Aml I.68,Abourehab Mohammed A. S.9,Wafa Emad I.6,Alhaj-Suliman Suhaila O.6,Salem Aliasger K.610,Ghosh Pradipta3111213,Abuo-Rahma Gamal El-Din A.114,Hayallah Alaa M.1516,Abbas Samar H.1ORCID

Affiliation:

1. Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia, Egypt

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Sohag University, Sohag, Egypt

3. Department of Cellular and Molecular Medicine, University of California San Diego, La Jolla, CA, USA

4. Cancer Biology Department, Pharmacology and Experimental Oncology Unit, National Cancer Institute, Cairo University, Cairo, Egypt

5. Department of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia, Egypt

6. Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, IA, USA

7. Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Manufacturing, Deraya University, New Minia City, Minia, Egypt

8. Department of Pharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, Sohag University, Sohag, Egypt

9. Department of Pharmaceutics, Faculty of Pharmacy, Umm Al Qura University, Makkah, Saudi Arabia

10. Holden Comprehensive Cancer Center, University of Iowa, Iowa City, IA, USA

11. Department of Medicine, University of California San Diego, La Jolla, CA, USA

12. Rebecca and John Moore Comprehensive Cancer Center, University of California San Diego, La Jolla, CA, USA

13. Veterans Affairs Medical Center, La Jolla, CA, USA

14. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, Minia, Egypt

15. Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Assiut University, Assiut, Egypt

16. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Sphinx University, New Assiut, Egypt

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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