Discovery ofN-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents

Author:

Xue Wenjie12,Wang Yaling13,Lian Xu1,Li Xueyao1,Pang Jing4,Kirchmair Johannes5ORCID,Wu Kebin6,Han Zunsheng1,You Xuefu4,Zhang Hongmin6ORCID,Xia Jie1ORCID,Wu Song1

Affiliation:

1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

2. Department of Pharmacy, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Third Hospital of Shanxi Medical University, Taiyuan, China

3. School of Pharmacy, Jiangsu Ocean University, Lianyungang, China

4. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China

5. Division of Pharmaceutical Chemistry, Department of Pharmaceutical Sciences, University of Vienna, Vienna, Austria

6. Department of Biology, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Shenzhen Key Laboratory of Cell Microenvironment and SUSTech-HKU Joint Laboratories for Matrix Biology, Southern University of Science and Technology, Shenzhen, China

Funder

Chinese Academy of Medical Science

the Shanxi Bethune Hospital

State Administration of Foreign Experts Affairs P.R. China

Natural Science Foundation of Shanxi Province

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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