Identification of 1<i>H</i>-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study-Reference-Cited by-同舟云学术

Identification of 1H-pyrazolo[3,4-b]pyridine derivatives as novel and potent TBK1 inhibitors: design, synthesis, biological evaluation, and molecular docking study

Published:2022-05-19 Issue:1 Volume:37 Page:1411-1425
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Sun Yin¹²,Tang Haotian²³,Wang Xiaoyan¹²,Feng Fang²,Fan Tiantian²³,Zhao Dongmei¹,Xiong Bing²³,Xie Hua²³⁴,Liu Tongchao²

Affiliation:

1. Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang, P. R. China

2. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China

3. University of Chinese Academy of Sciences, Beijing, P. R. China

4. Zhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, P. R. China

Funder

Lingang Laboratory Grant

National Natural Science Foundation of China

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2022.2076674

Reference29 articles.

1. Targeting TANK-binding kinase 1 (TBK1) in cancer

2. TBK1, a central kinase in innate immune sensing of nucleic acids and beyond

3. TANK-binding kinase 1 (TBK1): An emerging therapeutic target for drug discovery

4. Advances in Targeting IKK and IKK-Related Kinases for Cancer Therapy

5. Crystal Structure and Mechanism of Activation of TANK-Binding Kinase 1

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