Design, synthesis and evaluation of quinolinone derivatives containing dithiocarbamate moiety as multifunctional AChE inhibitors for the treatment of Alzheimer’s disease

Author:

Fu Jie12,Bao Fengqi2,Gu Min2,Liu Jing3,Zhang Zhipeng4,Ding Jiaoli4,Xie Sai-Sai4ORCID,Ding Jinsong1

Affiliation:

1. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, China

2. Jiangsu Zeyun Pharmaceutical Co., Ltd, Xibei Town Industrial Park, Wuxi, China

3. School of Pharmacy, Jiangxi University of Traditional Chinese Medicine, Nanchang, PR China

4. National Pharmaceutical Engineering Center for Solid Preparation in Chinese Herbal Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang, China

Funder

National Natural Science Foundation of China

Optimisation of Drug Formulation and Early Clinical Evaluation

Jiangxi Outstanding Youth Talent Support Programme

Natural Science Foundation of Jiangxi, China

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Reference38 articles.

1. Comprehensive review of mechanisms of pathogenesis involved in Alzheimer’s disease and potential therapeutic strategies

2. Patterson C. World Alzheimer Report 2018—The state of the art of dementia research: New frontiers. London: Alzheimer’s Disease International (ADI); 2018.

3. Prince M, Comas-Herrera A, Knapp M, et al. World Alzheimer report 2016: Improving healthcare for people living with dementia: coverage, quality and costs now and in the future. London: Alzheimer’s Disease International (ADI); 2016.

4. The history of the cholinergic hypothesis

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