Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy-Reference-Cited by-同舟云学术

Design and synthesis of tricyclic terpenoid derivatives as novel PTP1B inhibitors with improved pharmacological property and in vivo antihyperglycaemic efficacy

Published:2019-11-19 Issue:1 Volume:35 Page:152-164
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Yang Lingling¹,Chen Feng¹,Gao Cheng¹,Chen Jiabao¹,Li Junyan¹,Liu Siyan¹,Zhang Yuanyuan²,Wang Zhouyu²,Qian Shan¹

Affiliation:

1. Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu, China

2. Department of Chemistry, College of Science, Xihua University, Chengdu, China

Funder

National Natural Science Foundation for the Youth of China

Chengdu Technology Innovation Research Project

Sichuan Science and Technology Innovation Seedling Project

Science and Technology Department of Sichuan Province

the Found of Sichuan Education Department

Open Project of School of Health Management of Xihua University

the Innovation Fund of Xihua Scholars, Undergraduate and Post Graduate from Xihua University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2019.1690481

Reference45 articles.

1. The worldwide epidemiology of type 2 diabetes mellitus—present and future perspectives

2. The global burden of diabetes and its complications: an emerging pandemic

3. Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes

4. Inhibition of the glucose transporter SGLT2 with dapagliflozin in pancreatic alpha cells triggers glucagon secretion

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