Development of the β-lactam type molecular scaffold for selective estrogen receptor α modulator action: synthesis and cytotoxic effects in MCF-7 breast cancer cells

Author:

Carr Miriam1,Knox Andrew J. S.12,Lloyd David G.2,Zisterer Daniela M.2,Meegan Mary J.1

Affiliation:

1. School of Pharmacy and Pharmaceutical Sciences, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland and

2. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Reference68 articles.

1. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008

2. Cancer incidence and mortality patterns in Europe: Estimates for 40 countries in 2012

3. European Network of Cancer Registries ENCR Factsheets Breast Cancer (BC) Factsheet September 2014. 2014. Available from: http://www.encr.eu/images/docs/factsheets/ENCR_Factsheet_Breast_2014.pdf

4. Cancer in Ireland. 2013: Annual report of the National Cancer Registry

5. Estrogen-Receptor Status and Outcomes of Modern Chemotherapy for Patients With Node-Positive Breast Cancer

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