Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development
Author:
Affiliation:
1. Department of Chemistry, Istanbul Technical University, Istanbul, Turkey;
2. Department of Pharmacy, University of Pisa, Pisa, Italy;
3. Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey
Publisher
Informa UK Limited
Subject
Drug Discovery,Pharmacology,General Medicine
Link
https://tandfonline.com/doi/pdf/10.1080/14756366.2016.1250756
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1. Selectivity of Avanafil, a PDE5 Inhibitor for the Treatment of Erectile Dysfunction: Implications for Clinical Safety and Improved Tolerability
2. Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction
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4. Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function
5. Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
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