Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development-Reference-Cited by-同舟云学术

Investigation of PDE5/PDE6 and PDE5/PDE11 selective potent tadalafil-like PDE5 inhibitors using combination of molecular modeling approaches, molecular fingerprint-based virtual screening protocols and structure-based pharmacophore development

Published:2017-01-01 Issue:1 Volume:32 Page:311-330
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Kayık Gülru¹²,Tüzün Nurcan Ş.¹,Durdagi Serdar³

Affiliation:

1. Department of Chemistry, Istanbul Technical University, Istanbul, Turkey;

2. Department of Pharmacy, University of Pisa, Pisa, Italy;

3. Department of Biophysics, School of Medicine, Bahcesehir University, Istanbul, Turkey

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://tandfonline.com/doi/pdf/10.1080/14756366.2016.1250756

Reference86 articles.

1. Selectivity of Avanafil, a PDE5 Inhibitor for the Treatment of Erectile Dysfunction: Implications for Clinical Safety and Improved Tolerability

2. Phosphodiesterase type 5 as a pharmacologic target in erectile dysfunction

3. Phosphodiesterase 5 inhibitors: current status and potential applications

4. Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function

5. Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction

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