Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-<i>d</i>]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors-Reference-Cited by-同舟云学术

Design, synthesis and antitumor evaluation of novel pyrazolo[3,4-d]pyrimidines incorporating different amino acid conjugates as potential DHFR inhibitors

Published:2022-11-16 Issue:1 Volume:38 Page:203-215
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Salem Ibrahim M.¹,Mostafa Samia M.¹,Salama Ismail¹^ORCID,El-Sabbagh Osama I.²,Hegazy Wael A. H.³⁴^ORCID,Ibrahim Tarek S.⁵⁶^ORCID

Affiliation:

1. Medicinal Chemistry Department, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt

2. Medicinal Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

3. Department of Microbiology and Immunology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

4. Pharmacy Program, Department of Pharmaceutical Sciences, Oman College of Health Sciences, Muscat, Oman

5. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia

6. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt

Funder

Deanship of Scientific Research (DSR), King Abdulaziz University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2022.2142786

Reference22 articles.

1. The renewed potential for folate antagonists in contemporary cancer chemotherapy

2. The Antifolates

3. Simultaneous Inhibition of Protein Kinase CK2 and Dihydrofolate Reductase Results in Synergistic Effect on Acute Lymphoblastic Leukemia Cells

4. Quantitative structure–activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance-associated protein 2 (rMrp2)

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