Discovery of novel enasidenib analogues targeting inhibition of mutant isocitrate dehydrogenase 2 as antileukaemic agents

Author:

Khalil Ahmed F.1ORCID,El-Moselhy Tarek F.1,El-Bastawissy Eman A.1,Abdelhady Rasha2ORCID,Younis Nancy S.3ORCID,El-Hamamsy Mervat H.1

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Tanta University, Tanta, Egypt

2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt

3. Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al Hofuf, Saudi Arabia

Funder

Scientific Research, King Faisal University, Saudi Arabia

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Reference60 articles.

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2. Word health organisation global cancer observatory estimated number of new cases in 2020 worldwide both sexes all ages. 2022. [accessed 17 April 2022]. https://gco.Iarc.Fr/today/online-analysis-table?V=2020&mode=cancer&mode_population=continents&population=900&populations=&key=asr&sex=0&cancer=39&type=0&statistic=5&prevalence=0&population_group=0&ages_group%5b%5d=0&ages_group%5b%5d=17&group_cancer=1&include_nmsc=0&include_nmsc_other=1#collapse-by_country

3. National cancer institute cancer stat facts: Leukemia. 2022. [accessed 14 April 2022]. https://seer.Cancer.Gov/statfacts/html/leuks.Html

4. American Cancer Society leukemia in children. 2022. [access 17 April 2022]. https://www.Cancer.Org/cancer/leukemia-in-children.Html

5. Targeting metabolic transformation for cancer therapy

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