Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase-Reference-Cited by-同舟云学术

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Different roles for the acyl chain and the amine leaving group in the substrate selectivity of N-Acylethanolamine acid amidase

Published:2021-01-01 Issue:1 Volume:36 Page:1410-1422
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Ghidini Andrea¹^ORCID,Scalvini Laura¹^ORCID,Palese Francesca²^ORCID,Lodola Alessio¹^ORCID,Mor Marco¹^ORCID,Piomelli Daniele²³⁴^ORCID

Affiliation:

1. Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Parma, Italy

2. Department of Anatomy and Neurobiology, University of California, Irvine, CA, USA

3. Department of Pharmaceutical Sciences, University of California, Irvine, CA, USA

4. Department of Biological Chemistry and Molecular Biology, University of California, Irvine, CA, USA

Funder

Italian Ministry for University and Research

National Institute of Health

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2021.1912035

Reference52 articles.

1. An acid amidase hydrolyzing anandamide as an endogenous ligand for cannabinoid receptors

2. N-Acylethanolamine Acid Amidase (NAAA): Structure, Function, and Inhibition

3. Purification and Characterization of an Acid Amidase Selective for N-Palmitoylethanolamine, a Putative Endogenous Anti-inflammatory Substance

4. Molecular Characterization of N-Acylethanolamine-hydrolyzing Acid Amidase, a Novel Member of the Choloylglycine Hydrolase Family with Structural and Functional Similarity to Acid Ceramidase

5. Predominant expression of lysosomal N-acylethanolamine-hydrolyzing acid amidase in macrophages revealed by immunochemical studies

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1. Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years;Pharmacological Reviews;2023-05-10

2. Two legume fatty acid amide hydrolase isoforms with distinct preferences for microbial- and plant-derived acylamides;Scientific Reports;2023-05-09

3. QSAR Studies on a Series of Pyrazole Azabicyclo [3.2.1] Octane Sulfonamides N-Acylethanolamine-Hydrolyzing Acid Amidase Inhibitors;Letters in Drug Design & Discovery;2023-04-18

4. A Sensitive Ultrahigh-Performance Liquid Chromatography/Tandem Mass Spectrometry Method for the Simultaneous Analysis of Phytocannabinoids and Endocannabinoids in Plasma and Brain;Cannabis and Cannabinoid Research;2022-11-11

5. Targeting NAAA counters dopamine neuron loss and symptom progression in mouse models of parkinsonism;Pharmacological Research;2022-08

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