Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine–hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer-Reference-Cited by-同舟云学术

Molecular design, synthesis and in vitro biological evaluation of thienopyrimidine–hydroxamic acids as chimeric kinase HDAC inhibitors: a challenging approach to combat cancer

Published:2021-01-01 Issue:1 Volume:36 Page:1290-1311
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Abdel-Atty Mona M.¹,Farag Nahla A.¹,Serya Rabah A. T.²,Abouzid Khaled A. M.²³,Mowafy Samar¹⁴

Affiliation:

1. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Misr International University, Cairo, Egypt

2. Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt

3. Organic and Medicinal Chemistry Department, Faculty of Pharmacy, University of Sadat City, Sadat City, Egypt

4. Department of Chemistry, University of Washington, Seattle, WA, USA

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2021.1933465

Reference55 articles.

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2. Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

3. Design, synthesis and biological evaluation of novel histone deacetylase inhibitors based on virtual screening

4. Selective pharmacological inhibitors of HDAC6 reveal biochemical activity but functional tolerance in cancer models

5. Next-generation of selective histone deacetylase inhibitors

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