Novel multi-target ligands of dopamine and serotonin receptors for the treatment of schizophrenia based on indazole and piperazine scaffolds–synthesis, biological activity, and structural evaluation

Author:

Stępnicki Piotr1ORCID,Wronikowska-Denysiuk Olga2ORCID,Zięba Agata1ORCID,Targowska-Duda Katarzyna M.3ORCID,Bartyzel Agata4ORCID,Wróbel Martyna Z.5ORCID,Wróbel Tomasz M.1,Szałaj Klaudia6ORCID,Chodkowski Andrzej5,Mirecka Karolina5,Budzyńska Barbara2ORCID,Fornal Emilia6ORCID,Turło Jadwiga5ORCID,Castro Marián78ORCID,Kaczor Agnieszka A.19

Affiliation:

1. Department of Synthesis and Chemical Technology of Pharmaceutical Substances, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland

2. Independent Laboratory of Behavioral Studies, Chair of Biomedical Sciences, Faculty of Biomedicine, Medical University of Lublin, Lublin, Poland

3. Department of Biopharmacy, Faculty of Pharmacy, Medical University of Lublin, Lublin, Poland

4. Department of General and Coordination Chemistry and Crystallography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University in Lublin, Lublin, Poland

5. Department of Drug Technology and Pharmaceutical Biotechnology, Faculty of Pharmacy, Medical University of Warsaw, Warsaw, Poland

6. Department of Bioanalytics, Faculty of Biomedicine, Medical University of Lublin, Lublin, Poland

7. Department of Pharmacology, Center for Research in Molecular Medicine and Chronic Diseases (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain

8. Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Santiago de Compostela, Spain

9. School of Pharmacy, University of Eastern Finland, Kuopio, Finland

Funder

National Science Centre

Interdisciplinary Centre for Mathematical and Computational Modelling (ICM), Warsaw, Poland

Spanish Ministry of Economy and Competitiveness

Medical University of Lublin, Poland

Medical University of Warsaw

European Union-NextGenerationEU

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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