Development of new thiazolidine-2,4-dione hybrids as aldose reductase inhibitors endowed with antihyperglycaemic activity: design, synthesis, biological investigations, and in silico insights

Author:

Hamdi Abdelrahman1ORCID,Yaseen Muhammad2ORCID,Ewes Wafaa A.1ORCID,Bhat Mashooq Ahmad3ORCID,Ziedan Noha I.4ORCID,El-Shafey Hamed W.1ORCID,Mohamed Ahmed A. B.5ORCID,Elnagar Mohamed R.67ORCID,Haikal Abdullah8ORCID,Othman Dina I. A.1,Elgazar Abdullah A.9ORCID,Abusabaa Ahmed H. A.10ORCID,Abdelrahman Kamal S.11ORCID,Soltan Osama M.11ORCID,Elbadawi Mostafa M.12ORCID

Affiliation:

1. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

2. Institute of Chemical Sciences, University of Swat, Swat, Pakistan

3. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia

4. Department of physical, mathematical and Engineering science, Faculty of science, Business and Enterprise, University of Chester, Chester, UK

5. Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

6. Pharmacology and Toxicology Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt

7. Department of Pharmacology, College of Pharmacy, The Islamic University, Najaf, Iraq

8. Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt

9. Department of Pharmacognosy, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

10. Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt

11. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut, Egypt

12. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

Funder

King Saud University, Riyadh, Saudi Arabia

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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