Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors-Reference-Cited by-同舟云学术

Binding investigation and preliminary optimisation of the 3-amino-1,2,4-triazin-5(2H)-one core for the development of new Fyn inhibitors

Published:2018-01-01 Issue:1 Volume:33 Page:956-961
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Poli Giulio¹,Lapillo Margherita¹,Granchi Carlotta¹^ORCID,Caciolla Jessica¹,Mouawad Nayla¹²,Caligiuri Isabella²,Rizzolio Flavio²³^ORCID,Langer Thierry⁴,Minutolo Filippo¹^ORCID,Tuccinardi Tiziano¹⁵^ORCID

Affiliation:

1. Department of Pharmacy, University of Pisa, Pisa, Italy;

2. Pathology Unit, Department of Molecular Biology and Translational Research, National Cancer Institute and Center for Molecular Biomedicine, Aviano (PN), Italy;

3. Department of Molecular Science and Nanosystems, Ca' Foscari Università di Venezia, Venezia-Mestre, Italy;

4. Department of Pharmaceutical Chemistry, Faculty of Life Sciences, University of Vienna, Vienna, Austria;

5. Sbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA, USA

Funder

University of Pisa

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2018.1469017

Reference47 articles.

1. Fyn

2. Morphological Differentiation of Oligodendrocytes Requires Activation of Fyn Tyrosine Kinase

3. MOBP levels are regulated by Fyn kinase and affect the morphological differentiation of oligodendrocytes