Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer’s disease

Author:

Zhu Jie1,Yang Hongyu1,Chen Yao2,Lin Hongzhi1,Li Qi1,Mo Jun1,Bian Yaoyao3,Pei Yuqiong2,Sun Haopeng1

Affiliation:

1. Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, China;

2. School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China;

3. School of Nursing, Nanjing University of Chinese Medicine, Nanjing, China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Jiangsu Province

Fundamental Research Funds for the Central Universities

Jiangsu Qing Lan Project, Top-notch Academic Programs Project of Jiangsu Higher Education Institutions

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Reference34 articles.

1. Recent global trends in the prevalence and incidence of dementia, and survival with dementia

2. Alzheimer’s Disease International. World Alzheimer Report 2015: The global impact of dementia: an analysis of prevalence, incidence, costs and trends. London: Alzheimer’s Disease International (ADI); 2015. Available at: https://www.alz.co.uk/research/world-report-2015

3. A review on Alzheimer's disease pathophysiology and its management: an update

4. Investigational drugs in Alzheimer's disease: current progress

5. Acetylcholinesterase and carbonic anhydrase inhibitory properties of novel urea and sulfamide derivatives incorporating dopaminergic 2-aminotetralin scaffolds

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