Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase-Reference-Cited by-同舟云学术

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Druggable cavities and allosteric modulators of the cell division cycle 7 (CDC7) kinase

Published:2024-01-11 Issue:1 Volume:39 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Rojas-Prats Elisa¹^ORCID,Martinez-Gonzalez Loreto¹²^ORCID,Gil Carmen¹^ORCID,Ramírez David³^ORCID,Martinez Ana¹²^ORCID

Affiliation:

1. Centro de Investigaciones Biológicas -Margarita Salas-CSIC, Madrid, Spain

2. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de 13 Salud Carlos III, Madrid, Spain

3. Departamento de Farmacología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile

Funder

La Caixa and Luzón Foundation

MECD

Agencia Nacional de Investigación y Desarrollo - Chile

European Union Next Generation EU/PRTR

Spanish Health Institute Carlos III

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2024.2301767

Reference40 articles.

1. Genetic control of the cell division cycle in yeast;Hartwell LH;Science,1974

2. Functions of mammalian Cdc7 kinase in initiation/monitoring of DNA replication and development;Kim JM;Mutat Res,2003

3. Molecular mechanism of activation of human Cdc7 kinase: bipartite interaction with Dbf4/activator of S phase kinase (ASK) activation subunit stimulates ATP binding and substrate recognition;Kitamura R;J Biol Chem,2011

4. Targeting CDC7 potentiates ATR-CHK1 signaling inhibition through induction of DNA replication stress in liver cancer;Guo Y;Genome Med,2021

5. Overexpression of cell division cycle 7 homolog is associated with gene amplification frequency in breast cancer;Choschzick M;Hum Pathol,2010

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