Crystal structure of dihydroneopterin aldolase from <i>Mycobacterium tuberculosis</i> associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, <i>in vitro</i> toxicity and antitubercular activity-Reference-Cited by-同舟云学术

Crystal structure of dihydroneopterin aldolase from Mycobacterium tuberculosis associated with 8-mercaptoguanine, and development of novel S8-functionalized analogues as inhibitors: Synthesis, enzyme inhibition, in vitro toxicity and antitubercular activity

Published:2024-08-14 Issue:1 Volume:39 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Czeczot Alexia de Matos¹²,Muniz Mauro Neves¹,Perelló Marcia Alberton¹,Silva Éverton Edésio Dinis¹,Timmers Luís Fernando Saraiva Macedo³,Berger Andresa¹⁴,Gonzalez Laura Calle¹⁴,Arraché Gonçalves Guilherme¹²,Moura Sidnei⁵,Machado Pablo¹²⁴,Bizarro Cristiano Valim¹⁴,Basso Luiz Augusto¹²⁴

Affiliation:

1. Centro de Pesquisas em Biologia Molecular e Funcional, Instituto Nacional de Ciência e Tecnologia em Tuberculose, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil

2. Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil

3. Programa de Pós-Graduação em Biotecnologia, Universidade do Vale do Taquari, Lajeado, Brazil

4. Programa de Pós-Graduação em Biologia Celular e Molecular, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil

5. Laboratório de Biotecnologia de Produtos Naturais e Sintéticos, Instituto de Biotecnologia, Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul, Brazil

Funder

Banco Nacional de Desenvolvimento Econômico e Social

National Institute of Science and Technology on Tuberculosis

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2024.2388207

Reference23 articles.

1. World Health Organization. Global tuberculosis report. 2023.

2. The End TB Strategy. World Health Organization. 2015.

3. World Health Organization. Global tuberculosis report. 2022. 27:326–336.

4. Opportunities for overcoming tuberculosis: Emerging targets and their inhibitors

5. Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development