Challenging the Biginelli scaffold to surpass the first line antitubercular drugs: <i>Mycobacterium tuberculosis</i> thymidine monophosphate kinase (TMPK <i>mt</i> ) inhibition activity and molecular modelling studies-Reference-Cited by-同舟云学术

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Challenging the Biginelli scaffold to surpass the first line antitubercular drugs: Mycobacterium tuberculosis thymidine monophosphate kinase (TMPK mt ) inhibition activity and molecular modelling studies

Published:2024-09-11 Issue:1 Volume:39 Page:
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

El-Shoukrofy Mai S.¹^ORCID,Atta Amal¹,Fahmy Salwa¹,Sriram Dharmarajan²,Shehat Michael G.³^ORCID,Labouta Ibrahim M.¹^ORCID,Mahran Mona A.¹^ORCID

Affiliation:

1. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

2. Medicinal Chemistry Research Laboratory, Pharmacy Group, Birla Institute of Technology and Science, Pilani, India

3. Department of Microbiology and Immunology, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt

Publisher

Informa UK Limited

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2024.2386668

Reference73 articles.

1. Drug design and identification of potent leads against Mycobacterium tuberculosis thymidine monophosphate kinase;Van Calenbergh S;Curr Top Med Chem,2012

2. Pyrimidine derivatives with antitubercular activity

3. Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors

4. Global Tuberculosis Report. 2022. Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2022.

5. Screening approaches and therapeutic targets: The two driving wheels of tuberculosis drug discovery

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