Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights-Reference-Cited by-同舟云学术

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights

Published:2020-01-01 Issue:1 Volume:35 Page:1616-1630
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Sabt Ahmed¹,Eldehna Wagdy M.²,Al-Warhi Tarfah³,Alotaibi Ohoud J.³,Elaasser Mahmoud M.⁴,Suliman Howayda⁵,Abdel-Aziz Hatem A.⁶

Affiliation:

1. Chemistry of Natural Compounds Department, National Research Centre, Dokki, Egypt

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

3. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

4. The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo, Egypt

5. Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt

6. Department of Applied Organic Chemistry, National Research Center, Giza, Egypt

Funder

Deanship of Scientific Research at Princess Nourah bint Abdulrahman University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/14756366.2020.1806259

Reference54 articles.

1. An overview of targeted cancer therapy

2. Cdks, cyclins and CKIs: roles beyond cell cycle regulation

3. Cell-Cycle Therapeutics Come of Age

4. Recent development of CDK inhibitors: An overview of CDK/inhibitor co-crystal structures

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