Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights

Author:

Sabt Ahmed1,Eldehna Wagdy M.2,Al-Warhi Tarfah3,Alotaibi Ohoud J.3,Elaasser Mahmoud M.4,Suliman Howayda5,Abdel-Aziz Hatem A.6

Affiliation:

1. Chemistry of Natural Compounds Department, National Research Centre, Dokki, Egypt

2. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt

3. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia

4. The Regional Center for Mycology and Biotechnology, Al-Azhar University, Cairo, Egypt

5. Department of Medical Biochemistry, Faculty of Medicine, Alexandria University, Alexandria, Egypt

6. Department of Applied Organic Chemistry, National Research Center, Giza, Egypt

Funder

Deanship of Scientific Research at Princess Nourah bint Abdulrahman University

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

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