The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1-Reference-Cited by-同舟云学术

The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1

Published:2019-01-01 Issue:1 Volume:34 Page:361-374
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Xu Xinyuan¹,Chen Yingyi¹,Fu Qiang²,Ni Duan¹,Zhang Jian¹,Li Xiaolong³,Lu Shaoyong¹

Affiliation:

1. Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;

2. Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China;

3. Department of Orthopedics, Changhai Hospital, Naval Military Medical University, Shanghai, China

Funder

National Natural Science Foundation of China

Publisher

Informa UK Limited

Subject

Drug Discovery,Pharmacology,General Medicine

Link

https://tandfonline.com/doi/pdf/10.1080/14756366.2018.1553167

Reference103 articles.

1. PDK1, the master regulator of AGC kinase signal transduction

2. Ribosomal S6 Kinase Signaling and the Control of Translation

3. Hypomorphic Mutation of PDK1 Suppresses Tumorigenesis in PTEN+/− Mice

4. A phosphoserine-regulated docking site in the protein kinase RSK2 that recruits and activates PDK1

5. 90-kDa Ribosomal S6 Kinase Is Phosphorylated and Activated by 3-Phosphoinositide-dependent Protein Kinase-1

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