Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania-Reference-Cited by-同舟云学术

Mechanistic and biological characterisation of novel N5-substituted paullones targeting the biosynthesis of trypanothione in Leishmania

Published:2020-01-01 Issue:1 Volume:35 Page:1345-1358
ISSN:1475-6366
Container-title:Journal of Enzyme Inhibition and Medicinal Chemistry
language:en
Short-container-title:Journal of Enzyme Inhibition and Medicinal Chemistry

Author:

Medeiros Andrea¹²^ORCID,Benítez Diego¹^ORCID,Korn Ricarda S.³,Ferreira Vinicius C.⁴,Barrera Exequiel⁵^ORCID,Carrión Federico⁶,Pritsch Otto⁶⁷,Pantano Sergio⁵^ORCID,Kunick Conrad³^ORCID,de Oliveira Camila I.⁴,Orban Oliver C. F.³^ORCID,Comini Marcelo A.¹^ORCID

Affiliation:

1. Laboratory Redox Biology of Trypanosomes, Institut Pasteur de Montevideo, Montevideo, Uruguay

2. Departamento de Bioquímica, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay

3. Institut für Medizinische und Pharmazeutische Chemie, Technische Universität Braunschweig, Braunschweig, Germany

4. Instituto Gonçalo Moniz (IGM), FIOCRUZ, Salvador, Brazil

5. Biomolecular Simulations Group, Institut Pasteur de Montevideo, Montevideo, Uruguay

6. Protein Biophysics Unit, Institut Pasteur de Montevideo, Montevideo, Uruguay

7. Departamento de Inmunobiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

Funder

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Comisión Sectorial de Investigación Científica

Universidad de la República Uruguay