Safety and Efficacy of Vaccination Against Influenza in Patients With Rheumatoid Arthritis

Author:

Elkayam Ori1

Affiliation:

1. Departments of Internal Medicine and Rheumatology, Tel Aviv Medical Center and the “Sackler” School of Medicine, University of Tel Aviv, Israel

Abstract

Vaccination against influenza is currently recommended for patients with rheumatoid arthritis (RA). The safety and efficacy of vaccination in patients suffering from rheumatic diseases is still a matter of debate. This review summarizes the studies performed on the safety and immunogenicity of influenza vaccination in patients with RA as well as the rheumatic complications of the vaccine in otherwise healthy persons. Several trials have shown that the vaccine induces an adequate humoral response and does not induce clinical exacerbation of RA. Rheumatic complications (mainly vasculitis) following influenza vaccination in the general population are scarce.

Publisher

Hindawi Limited

Subject

General Medicine,Immunology,Immunology and Allergy

Reference20 articles.

1. Arnold, CM and Hochberg, MC. (1989) Development of an immunization program for patients with rheumatoid arthritis Arthritis Care Res, 2, pp. 162 - 164.

2. Biasi, D and Carletto, A and Caramaschi, P and Tonoli, M and Bambara, LM. (1994) A case of reactive arthritis after influenza vaccination Clin Rheumatol, 13(4), pp. 645.

3. Blumberg, S and Bienfang, D and Kantrowitz, FG. (1980) A possible association between influenza vaccination and small-vessel vasculitis Arch Intern Med, 140(6), pp. 847 - 848.

4. Bridges, MJ and Coady, D and Kelly, CA and Hamilton, J and Heycock, C. (2003) Factors influencing uptake of influenza vaccination in patients with rheumatoid arthritis Ann Rheum Dis, 62(7), pp. 685.

5. Center for Disease Control and Prevention: Prevention and control of influenza, recommendation of the Advisory Committee on Immunization Practice. 2002. Morb Mortal Wkly Rep

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