Quality-by-design-based microemulsion of disulfiram for repurposing in melanoma and breast cancer therapy

Author:

Mohapatra Debadatta1ORCID,Senapati Prakash Ch2ORCID,Senapati Shantibhusan3ORCID,Pandey Vivek4ORCID,Dubey Pawan K4ORCID,Singh Sanjay5ORCID,Sahu Alakh N1ORCID

Affiliation:

1. Phytomedicine Research Laboratory, Department of Pharmaceutical Engineering & Technology, IIT (BHU), Varanasi- 221005, Uttar Pradesh, India

2. IMT Pharmacy College, Gopalpur, Puri 752004, Odisha, India

3. Tumor Microenvironment & Animal Models Laboratory, Institute of Life Sciences, Bhubaneswar- 751023, Odisha, India

4. Centre for Genetics Disorders, Institute of Science (BHU), Varanasi 221005, Uttar Pradesh, India

5. Nanomedicine Research Laboratory, Department of Pharmaceutical Engineering & Technology, IIT (BHU), Varanasi- 221005, Uttar Pradesh, India

Publisher

Informa UK Limited

Reference92 articles.

1. Time December 6 Health & Medicine Medicine: Drug for Drunks 1948; see also Time January 10 Health & Medicine Medicine: The Loaded Canapes. 1949.

2. Kragh HJBHC. From disulfiram to antabuse: the invention of a drug. 2008;33(2):82–88.

3. US FDA. Drug Approvals and Databases antabuse 28-08-1951. https://www.fda.gov/drugs/development-approval-process-drugs/drug-approvals-and-databases

4. Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease

5. Development of disulfiram-loaded vaginal rings for the localised treatment of cervical cancer

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