Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745-Reference-Cited by-同舟云学术

Production of 17-O-demethyl-geldanamycin, a cytotoxic ansamycin polyketide, by Streptomyces hygroscopicus DEM20745

Published:2016-12-14 Issue:16 Volume:31 Page:1895-1900
ISSN:1478-6419
Container-title:Natural Product Research
language:en
Short-container-title:Natural Product Research

Author:

Baksh Aron¹,Kepplinger Bernhard¹²,Isah Hadiza A.³,Probert Michael R.³,Clegg William³,Wills Corinne³,Goodfellow Michael⁴,Errington Jeff⁵,Allenby Nick¹,Hall Michael J.³^ORCID

Affiliation:

1. Faculty of Medical Sciences, Demuris Limited, Newcastle Biomedicine Bio-Incubators, Newcastle upon Tyne, UK

2. Industrial Doctorate Centre: Biopharmaceutical Process Development, Newcastle University, Newcastle upon Tyne, UK

3. School of Chemistry, Newcastle University, Newcastle upon Tyne, UK

4. School of Biology, Newcastle University, Newcastle upon Tyne, UK

5. Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle upon Tyne, UK

Funder

Engineering and Physical Sciences Research Council

Publisher

Informa UK Limited

Subject

Organic Chemistry,Plant Science,Biochemistry,Analytical Chemistry

Link

https://www.tandfonline.com/doi/pdf/10.1080/14786419.2016.1263854

Reference30 articles.

1. Geldanamycin-associated Inhibition of Intracellular Trafficking Is Attributed to a Co-purified Activity

2. Production of 8-Demethylgeldanamycin and 4,5-Epoxy-8-demethylgeldanamycin from a Recombinant Strain of Streptomyces hygroscopicus

3. Reaction of Geldanamycin and C17-Substituted Analogues with Glutathione: Product Identifications and Pharmacological Implications

4. GELDANAMYCIN, A NEW ANTIBIOTIC

5. Broad Substrate Specificity of the Amide Synthase in S. hygroscopicus—New 20-Membered Macrolactones Derived from Geldanamycin

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