Discovery of potent inhibitors for Mpro enzyme of SARS-COV2 by multi-stage in-silico screening of Alkannin/shikonin-Reference-Cited by-同舟云学术

Discovery of potent inhibitors for Mpro enzyme of SARS-COV2 by multi-stage in-silico screening of Alkannin/shikonin

Published:2021-12-15 Issue: Volume: Page:1-5
ISSN:1478-6419
Container-title:Natural Product Research
language:en
Short-container-title:Natural Product Research

Author:

Kumar Nitish¹²^ORCID,Singh Jatinder Vir¹,Bhagat Kavita¹,Gulati Harmandeep Kaur¹,Sharma Anchal¹,Rani Archana¹,Duggal Amit³,Gulati Puja⁴,Singh Harbinder¹,Bedi Preet Mohinder Singh¹²,Kaur Sarabjit¹

Affiliation:

1. Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar, Punjab, India

2. Drug and Pollution Testing Laboratory, Guru Nanak Dev University, Amritsar, Punjab, India

3. Drugs Control Wing, Chandigarh, India

4. School of Pharmacy, Desh Bhagat University, Mandi Gobindgarh, Punjab, India

Publisher

Informa UK Limited

Subject

Organic Chemistry,Plant Science,Biochemistry,Analytical Chemistry

Link

https://www.tandfonline.com/doi/pdf/10.1080/14786419.2021.2013212

Reference12 articles.

1. Origin and evolution of pathogenic coronaviruses

2. Application of “macromolecular crowding” in vitro to investigate the naphthoquinones shikonin, naphthazarin and related analogues for the treatment of dermal scars

3. A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease

4. Identification of potential Mpro inhibitors for the treatment of COVID-19 by using systematic virtual screening approach

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3. Shikonin and Alkannin inhibit ATP synthase and impede the cell growth in Escherichia coli;International Journal of Biological Macromolecules;2023-12

4. Shikonin, an inhibitor of inflammasomes, inhibits Epstein-Barr virus reactivation;Antiviral Research;2023-09

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