Aaptamine derivatives with CDK2 inhibitory activities from the South China Sea sponge Aaptos suberitoides

Author:

He Qian-Qian12,Man Yu-Qing12,Sun Kun-Lai3,Yang Li-Juan1,Wu Yan1,Du Jing1,Chen Wei-Wei1,Dai Juan-Juan1,Ni Na1,Miao Shuang1,Gong Kai-Kai1ORCID

Affiliation:

1. Cancer Research Institute, Binzhou Medical University Hospital, Binzhou, China

2. Department of Pharmacy, Binzhou Medical University Hospital, Binzhou, China

3. Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food and Pharmacy, Zhejiang Ocean University, Zhoushan, China

Funder

National Natural Science Foundation of China

Natural Science Foundation of Shandong Province

Traditional Chinese Medicine Technology Development Foundation of Shandong

Science and Technology Development Foundation of Binzhou

Research Foundation of Binzhou Medical University

Publisher

Informa UK Limited

Subject

Organic Chemistry,Plant Science,Biochemistry,Analytical Chemistry

Reference24 articles.

1. Drug Affinity Responsive Target Stability (DARTS) Identifies Laurifolioside as a New Clathrin Heavy Chain Modulator

2. Zebra Mussel Antifouling Activity of the Marine Natural Product Aaptamine and Analogs

3. Proliferation, cell cycle and apoptosis in cancer

4. Gong K, He Q, Miao S, Man Y, inventors; Binzhou Medical University Hospital, Patent holder; Jinan Fangyu Patent Office, assignee. 2020 Dec 15. Preparation of marine alkaloid CDK2 inhibitors as antitumor drugs. China patent. CN 202011473519.3.

5. Aaptamine attenuates the proliferation and progression of non-small cell lung carcinoma

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