Emerging vistas in CAR T-cell therapy: challenges and opportunities in solid tumors

Author:

Date Varada1,Nair Sujit2ORCID

Affiliation:

1. Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS University, Mumbai, India

2. SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, University of Mumbai, Mumbai, India

Funder

not funded

Publisher

Informa UK Limited

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology

Reference135 articles.

1. Cancer statistics, 2019

2. Novartis. Novartis receives first ever FDA approval for a CAR-T cell therapy, Kymriah™ (tisagenlecleucel, CTL019), for children and young adults with B-cell ALL that is refractory or has relapsed at least twice novartis [Online]; 2017. Available from: https://novartis.gcs-web.com/novartis-receives-fda-approval-for-KymriahTM

3. Institute NC. Tisagenlecleucel (Kymriah) approved to treat some lymphomas; 2018 [cited 2019 Jul 22]. Available from: https://www.cancer.gov/news-events/cancer-currents-blog/2018/tisagenlecleucel-fda-lymphoma

4. Gilead. Kite’s Yescarta™ (Axicabtagene Ciloleucel) becomes first CAR T therapy approved by the FDA for the treatment of adult patients with relapsed or refractory large B-cell lymphoma after two or more lines of systemic therapy gilead [Online]; 2017. Available from: http://www.gilead.com/news/press-releases/2017/10/kites-yescarta-axicabtagene-ciloleucel-becomes-first-car-t-therapy-approved-by-the-fda-for-the-treatment-of-adult-patients-with-relapsed-or-refractory-large-bcell-lymphoma-after-two-or-more-lines-of-systemic-therapy

5. Novartis. Novartis receives European commission approval of its CAR-T cell therapy, Kymriah® (tisagenlecleucel) novartis. [Online]; 2018. Available from: https://www.novartis.com/news/media-releases/novartis-receives-european-commission-approval-its-car-t-cell-therapy-kymriah-tisagenlecleucel

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