Extensive genomic analysis in patients with <i>KRAS</i>-mutated solid tumors shows high frequencies of concurrent alterations and potential targets but has limited clinical impact-Reference-Cited by-同舟云学术

Extensive genomic analysis in patients with KRAS-mutated solid tumors shows high frequencies of concurrent alterations and potential targets but has limited clinical impact

Published:2022-12-02 Issue:12 Volume:61 Page:1499-1506
ISSN:0284-186X
Container-title:Acta Oncologica
language:en
Short-container-title:Acta Oncologica

Author:

Jacobsen Ida Christine¹^ORCID,Spanggaard Iben¹,Højgaard Martin¹,Belcaid Laïla¹,Qvortrup Camilla¹,Yde Christina Westmose²,Schmidt Ane Yde²,Nielsen Finn Cilius²,Willemoe Gro Linno³,Dam Mikkel Seidelin⁴,Lassen Ulrik¹,Staal Rohrberg Kristoffer¹

Affiliation:

1. Phase 1 Unit, Department of Oncology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark

2. Center for Genomic Medicine, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark

3. Department of Pathology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark

4. Department of Diagnostic Radiology, Rigshospitalet, University Hospital of Copenhagen, Copenhagen, Denmark

Funder

Capitol Region of Denmark

Publisher

Informa UK Limited

Subject

Radiology, Nuclear Medicine and imaging,Oncology,Hematology,General Medicine

Link

https://www.tandfonline.com/doi/pdf/10.1080/0284186X.2022.2156809

Reference40 articles.

1. KRAS Mutations as Prognostic and Predictive Markers in Non–Small Cell Lung Cancer

2. RAS isoforms and mutations in cancer at a glance

3. Impact of KRAS mutation subtype and concurrent pathogenic mutations on non-small cell lung cancer outcomes

4. K-ras Mutation Subtypes in NSCLC and Associated Co-occuring Mutations in Other Oncogenic Pathways

5. Pancreatic cancer: optimizing treatment options, new, and emerging targeted therapies