1. Academic Unit of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK;
2. Integrative Physiology and Critical Illness Group, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK;
3. Department of Medicine, Institute for Sport, Exercise and Health, University College London, London, UK;
4. National Institute for Health Research, Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK;
5. Department of Oncology, University Hospital Southampton NHS Foundation Trust, Southampton, UK;
6. Department of Radiology, Aintree University Hospital NHS Foundation Trust, Liverpool, UK;
7. Anaesthesia and Critical Care Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, UK;
8. Department of Radiology, The Royal Marsden NHS Foundation Trust, London, UK