Can differences in linear energy transfer and thus relative biological effectiveness compromise the dosimetric advantage of intensity-modulated proton therapy as compared to passively scattered proton therapy?
Author:
Affiliation:
1. Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
Funder
National Cancer Institute
Publisher
Informa UK Limited
Subject
Radiology Nuclear Medicine and imaging,Oncology,Hematology,General Medicine
Link
https://www.tandfonline.com/doi/pdf/10.1080/0284186X.2018.1468090
Reference18 articles.
1. Intensity-Modulated Proton Therapy Reduces the Dose to Normal Tissue Compared With Intensity-Modulated Radiation Therapy or Passive Scattering Proton Therapy and Enables Individualized Radical Radiotherapy for Extensive Stage IIIB Non-Small-Cell Lung Cancer: A Virtual Clinical Study
2. The rationale for intensity-modulated proton therapy in geometrically challenging cases
3. Relative biological effectiveness (RBE) values for proton beam therapy. Variations as a function of biological endpoint, dose, and linear energy transfer
4. Variations in Linear Energy Transfer Within Clinical Proton Therapy Fields and the Potential for Biological Treatment Planning
5. Linear Energy Transfer-Guided Optimization in Intensity Modulated Proton Therapy: Feasibility Study and Clinical Potential
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