Abstract
PPG-5 Lanolin Wax and PPG-5 Lanolin Wax Glyceride are used in cosmetic formualations as skin conditioning agents–emollients. The basic components of these polypropylene glycol (PPG) derivatives were reviewed by the CIR Expert Panel. PPG was found to be safe for use in cosmetic products as concentrations of up to 50%. Lanolin Wax was found to be safe for topical application in the present practices of use and concentration (which ranged from 0.1% to 50%). Subchronic oral studies on the two PPG derivatives covered in this report indicate no systemic toxicity in rats. Ocular irritation in animals was reported to be minimal, as was dermal irritation. Clinical testing found no irritation upon treatment with 7.5% PPG-5 Lanolin Wax (as contained in an eye shadow formulation), and no sensitization in a repeated insult patch test using 3.9% PPG-5 Lanolin Wax (as contained in a lipstick). In addition to these limited data on PPG-5 Lanolin Wax and PPG-5 Lanolin Wax Glyceride, the previous reports were reviewed and synopses of relevant sections included in this report. On the basis of the available data specific to these twoingredients, as well as the data previously considered in the reports on PPG and Lanolin Wax, it is concluded that PPG-5 Lanolin Wax and PPG-5 Lanolin Wax Glyceride are safe as used in cosmetics.
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