Rapid quantitation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in rat urine using ultra-fast liquid chromatography mass spectrometry (UFLC/MS/MS)
Author:
Affiliation:
1. Division of Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, AR, USA
Funder
Center for Tobacco Products, U.S. Food and Drug Administration
Publisher
Informa UK Limited
Subject
Clinical Biochemistry,Pharmaceutical Science,Biochemistry,Analytical Chemistry
Link
https://www.tandfonline.com/doi/pdf/10.1080/10826076.2018.1441156
Reference20 articles.
1. Application of an assay for 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) in urine for the assessment of tobacco-related harm
2. Hazardous Compounds in Tobacco Smoke
3. Application of toxicological risk assessment principles to the chemical constituents of cigarette smoke
4. Research Opportunities Related to Establishing Standards for Tobacco Products Under the Family Smoking Prevention and Tobacco Control Act
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1. 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats;Food and Chemical Toxicology;2022-02
2. 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats;Toxicological Sciences;2021-07-30
3. A new method for the simultaneous determination of urinary NNAL and cotinine concentrations using HILIC-MS/MS coupled with PRiME HLB SPE;International Journal of Mass Spectrometry;2021-07
4. Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage;Toxicological Sciences;2021-05-03
5. Identification and characterization of Nornicotine degrading strain Arthrobacter sp. NOR5;Science of The Total Environment;2021-04
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