Romidepsin (FK228) fails in counteracting the transformed phenotype of rhabdomyosarcoma cells but efficiently radiosensitizes, in vitro and in vivo, the alveolar phenotype subtype

Author:

Rossetti Alessandra1,Petragnano Francesco1,Milazzo Luisa2,Vulcano Francesca2,Macioce Giampiero2,Codenotti Silvia3,Cassandri Matteo4,Pomella Silvia4,Cicchetti Francesca5,Fasciani Irene1,Antinozzi Cristina6,Di Luigi Luigi6ORCID,Festuccia Claudio1,De Felice Francesca7,Vergine Massimo8,Fanzani Alessandro3,Rota Rossella4,Maggio Roberto1,Polimeni Antonella9,Tombolini Vincenzo7,Gravina Giovanni Luca1,Marampon Francesco7

Affiliation:

1. Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, Italy

2. Department of Oncology and Molecular Medicine, Istituto Superiore di Sanità, Rome, Italy

3. Division of Biotechnology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy

4. Group of Epigenetics of Pediatric Sarcomas, Department of Oncohematology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

5. Policlinico Umberto I Hospital, Roma, Italy

6. Unit of Endocrinology, Department of Movement, Human and Health Sciences, University of Rome “Foro Italico”, Rome, Italy

7. Department of Radiotherapy, Policlinico Umberto I, “Sapienza” University of Rome, Rome, Italy

8. Department of Surgical Sciences, “Sapienza” University of Rome, Rome, Italy

9. Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Rome, Italy

Funder

AIRC

the University of Roma, Sapienza

Publisher

Informa UK Limited

Subject

Radiology Nuclear Medicine and imaging,Radiological and Ultrasound Technology

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