Development of an adverse outcome pathway for radiation-induced microcephaly via expert consultation and machine learning

Author:

Jaylet Thomas1,Quintens Roel2ORCID,Benotmane Mohamed Abderrafi2ORCID,Luukkonen Jukka3ORCID,Tanaka Ignacia Braga4ORCID,Ibanez Chrystelle5,Durand Christelle5,Sachana Magdalini6,Azimzadeh Omid7ORCID,Adam-Guillermin Christelle8,Tollefsen Knut Erik91011ORCID,Laurent Olivier12,Audouze Karine1ORCID,Armant Olivier13ORCID

Affiliation:

1. Université Paris Cité, T3S, Inserm UMRS 1124, Paris, France

2. Radiobiology Unit, Belgian Nuclear Research Centre, SCK-CEN, Mol, Belgium

3. Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio Campus, Kuopio, Finland

4. Department of Radiobiology, Institute for Environmental Sciences, Aomori, Japan

5. PSE-SANTE/SESANE/LRTOX Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France

6. Organisation for Economic Co-operation and Development (OECD), Environment Health and Safety Division, Paris, France

7. Federal Office for Radiation Protection (Bfs), Section Radiation Biology, Neuherberg, Germany

8. PSE-SANTE/SDOS/LMDN, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Saint-Paul-Lez-Durance, France

9. Norwegian Institute for Water Research (NIVA), Oslo, Norway

10. Norwegian University of Life Sciences (NMBU), Ås, Norway

11. Centre for Environmental Radioactivity, Norwegian University of Life Sciences (NMBU), Ås, Norway

12. PSE-SANTE/SESANE/LEPID, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Fontenay-aux-Roses, France

13. PSE-ENV/SRTE/LECO, Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Saint-Paul-Lez-Durance, France

Funder

Euratom research and training program

-

under grant agreement

Research Council of Norway (RCN) through its Centre for Excellence funding scheme

NIVAS Computational Toxicology Program, NCTP

Publisher

Informa UK Limited

Subject

Radiology, Nuclear Medicine and imaging,Radiological and Ultrasound Technology

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