Novel benzimidazole angiotensin receptor blockers with anti-SARS-CoV-2 activity equipotent to that of nirmatrelvir: computational and enzymatic studies

Author:

Ridgway Harry12,Moore Graham J.34,Gadanec Laura Kate5ORCID,Zulli Anthony5ORCID,Apostolopoulos Vasso56ORCID,Hoffmann Weronika7,Węgrzyn Katarzyna7ORCID,Vassilaki Niki8ORCID,Mpekoulis George8,Zouridakis Marios9ORCID,Giastas Petros910,Vidali Veroniki P.11ORCID,Kelaidonis Konstantinos12,Matsoukas Minos-Timotheos13ORCID,Dimitriou Marios14,Mavromoustakos Thomas15ORCID,Tsiodras Sotirios16ORCID,Gorgoulis Vassilis G.1718192021ORCID,Karakasiliotis Ioannis14,Chasapis Christos T.22ORCID,Matsoukas John M.5122324ORCID

Affiliation:

1. Institute for Sustainable Industries and Liveable Cities, Victoria University, Melbourne, Australia

2. AquaMem Consultants, Rodeo, NM, USA

3. Pepmetics Inc, 772 Murphy Place, Victoria, BC, Canada

4. Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

5. Institute for Health and Sport, Immunology and Translational Research, Victoria University, Melbourne, Australia

6. Immunology Program, Australian Institute for Musculoskeletal Science (AIMSS), Melbourne, Australia

7. Laboratory of Molecular Biology, Intercollegiate Faculty of Biotechnology of University of Gdańsk and Medical University of Gdańsk, Gdańsk, Poland

8. Laboratory of Molecular Virology, Hellenic Pasteur Institute, Athens, Greece

9. Structural Neurobiology Research Group, Laboratory of Molecular Neurobiology and Immunology, Hellenic Pasteur Institute, Athens, Greece

10. Department of Biotechnology, Agricultural University of Athens, Athens, Greece

11. Natural Products and Bioorganic Chemistry Laboratory, Institute of Nanoscience & Nanotechnology, NCSR “Demokritos”, Athens, Greece

12. NewDrug PC, Patras Science Park, Patras, Greece

13. Department of Biomedical Engineering, University of West Attica, Athens, Greece

14. Laboratory of Biology, Department of Medicine, Democritus University of Thrace, Xanthi, Greece

15. Department of Chemistry, Laboratory of Organic Chemistry, National Kapodistrian University of Athens, Athens, Greece

16. Faculty of Medicine, 4th Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece

17. Ninewells Hospital and Medical School, University of Dundee, Dundee, UK

18. Department of Histology and Embryology, Faculty of Medicine, National Kapodistrian University of Athens, Athens, Greece

19. Faculty Institute for Cancer Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK

20. Biomedical Research Foundation, Academy of Athens, Athens, Greece

21. Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey, UK

22. Institute of Chemical Biology, National Hellenic Research Foundation, Athens, Greece

23. Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Alberta, Canada

24. Department of Chemistry, University of Patras, Patras, Greece

Funder

Planetary Health

Publisher

Informa UK Limited

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