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Biomarker threshold adaptive designs for survival endpoints

Published:2018-02-13 Issue:6 Volume:28 Page:1038-1054
ISSN:1054-3406
Container-title:Journal of Biopharmaceutical Statistics
language:en
Short-container-title:Journal of Biopharmaceutical Statistics

Author:

Diao Guoqing¹^ORCID,Dong Jun²,Zeng Donglin³,Ke Chunlei²,Rong Alan⁴,Ibrahim Joseph G³

Affiliation:

1. Department of Statistics, George Mason University, Fairfax, Virginia, USA

2. Amgen Inc., Thousand Oaks, California, USA

3. Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

4. Astellas Pharma US, Inc., Los Angeles, California, USA

Publisher

Informa UK Limited

Subject

Pharmacology (medical),Pharmacology,Statistics and Probability

Link

https://www.tandfonline.com/doi/pdf/10.1080/10543406.2018.1434191

Reference12 articles.

1. The Cross-Validated Adaptive Signature Design

2. Adaptive Signature Design: An Adaptive Clinical Trial Design for Generating and Prospectively Testing A Gene Expression Signature for Sensitive Patients

3. Loss of PTEN expression predicts resistance to EGFR-targeted monoclonal antibodies in patients with metastatic colorectal cancer

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