Bayesian hierarchical model for dose-finding trial incorporating historical data

Author:

Han Linxi1,Deng Qiqi2,He Zhangyi3,Fleischer Frank4,Yu Feng1

Affiliation:

1. School of Mathematics, University of Bristol, Bristol, UK

2. Biostatistics and Data Sciences, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, Connecticut, USA

3. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

4. Biostatistics+Data Sciences Corp, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany

Funder

no funding

Publisher

Informa UK Limited

Subject

Pharmacology (medical),Pharmacology,Statistics and Probability

Reference19 articles.

1. Bayesian clinical trials

2. The use of the area under the ROC curve in the evaluation of machine learning algorithms

3. Combining Multiple Comparisons and Modeling Techniques in Dose-Response Studies

4. A Bayesian basket trial design using a calibrated Bayesian hierarchical model

5. European Medicines Agency (2014). Qualification opinion of MCP-Mod as an efficient statistical methodology for model-based design and analysis of Phase II dose finding studies under model uncertainty. https://www.ema.europa.eu/en/documents/regulatory-procedural-guideline/qualification-opinion-mcp-mod-efficient-statistical-methodology-model-based-design-analysis-phase-ii_en.pdf.

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