Hazard Evaluation Support System (HESS) for predicting repeated dose toxicity using toxicological categories

Author:

Sakuratani Y.,Zhang H.Q.,Nishikawa S.,Yamazaki K.,Yamada T.,Yamada J.,Gerova K.,Chankov G.,Mekenyan O.,Hayashi M.

Publisher

Informa UK Limited

Subject

Drug Discovery,Molecular Medicine,General Medicine,Bioengineering

Reference25 articles.

1. European Parliament and Council of the European Union,Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC, Annex VIII, Off. J. Eur. Union L396 (2006), pp. 330–343.

2. Organisation for Economic Co-operation and Development (OECD),OECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138. Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories, OECD, Paris, 2011.

3. Category analysis of the substituted anilines studied in a 28-day repeat-dose toxicity test conducted on rats: Correlation between toxicity and chemical structure

4. M. Hayashi and Y. Sakuratani,Hemolytic anemia induced by anilines and nephrotoxicity induced by 4-aminophenols, inOECD Environment, Health and Safety Publications Series on Testing and Assessment No. 138, Report of the Workshop on Using Mechanistic Information in Forming Chemical Categories, OECD, Paris, 2011, pp. 140–167.

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