Prediction of tissue and urine concentrations of 2-phenoxyethanol and its metabolite 2-phenoxyacetic acid in rat and human after oral and dermal exposures via GastroPlus<sup>TM</sup> physiologically based pharmacokinetic modelling-Reference-Cited by-同舟云学术

Prediction of tissue and urine concentrations of 2-phenoxyethanol and its metabolite 2-phenoxyacetic acid in rat and human after oral and dermal exposures via GastroPlus^TM physiologically based pharmacokinetic modelling

Published:2022-03-18 Issue:5 Volume:33 Page:323-339
ISSN:1062-936X
Container-title:SAR and QSAR in Environmental Research
language:en
Short-container-title:SAR and QSAR in Environmental Research

Author:

Zhang F.¹,LeBaron M.J.¹,Marty M.S.¹

Affiliation:

1. Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI, USA

Funder

work featured in this article

Publisher

Informa UK Limited

Subject

Drug Discovery,Molecular Medicine,General Medicine,Bioengineering

Link

https://www.tandfonline.com/doi/pdf/10.1080/1062936X.2022.2049866

Reference14 articles.

1. RIFM fragrance ingredient safety assessment, 2-phenoxyethanol, CAS Registry Number 122-99-6

2. 2-Phenoxyethanol [MAK Value Documentation, 2017]

3. Development of a physiologically-based pharmacokinetic model of 2-phenoxyethanol and its metabolite phenoxyacetic acid in rats and humans to address toxicokinetic uncertainty in risk assessment

4. Simultaneous determination of phenoxyethanol and its major metabolite, phenoxyacetic acid, in rat biological matrices by LC–MS/MS with polarity switching: Application to ADME studies

5. Safety review of phenoxyethanol when used as a preservative in cosmetics

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