A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation-Reference-Cited by-同舟云学术

A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation

Published:2016-02-01 Issue:2 Volume:80 Page:313-317
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Asahi Takashi¹²,Wu Xiaohong²³,Shimoda Hiroshi⁴,Hisaka Shinsuke⁵,Harada Etsuko⁶,Kanno Tomomi⁷,Nakamura Yoshimasa¹,Kato Yoji⁸,Osawa Toshihiko²⁹

Affiliation:

1. Graduate School of Environmental and Life Science, Okayama University, Okayama, Japan

2. Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Japan

3. HealthCare Systems Co., Ltd., Tokyo, Japan

4. Oryza Oil & Fat Chemical Co., Ltd., Ichinomiya, Japan

5. Faculty of Pharmacy, Department of Pharmacy, Meijo University, Nagoya, Japan

6. Iwade Research Institute of Mycology, Tsu, Japan

7. Hokkaido University of Education, Asahikawa, Japan

8. School of Human Science and Environment, University of Hyogo, Himeji, Japan

9. Faculty of Psychological and Physical Science, Aichi Gakuin University, Nissin, Japan

Abstract

Abstract Myeloperoxidase (MPO)-generated halogenating molecules, such as hypochlorous acid and hypobromous acid (HOBr), in inflammatory regions are postulated to contribute to disease progression. In this study, we showed that ergothioneine (EGT), derived from an edible mushroom, inhibited MPO activity as well as the formation of 8-bromo-2′-deoxyguanosine in vitro. The HOBr scavenging effect of EGT is higher than those of ascorbic acid and glutathione. We initially observed that the administration of Coprinus comatus, an edible mushroom containing a high amount of EGT, inhibited the UV-B-induced inflammatory responses and DNA halogenation, suggesting that EGT is a promising anti-inflammatory agent from mushrooms.

Funder

MEXT KAKENHI

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/80/2/313/36807219/bbb0313.pdf

Reference20 articles.

1. Studies on the chlorinating activity of myeloperoxidase;Harrison;J. Biol. Chem,1976

2. Neutrophils employ the myeloperoxidase system to generate antimicrobial brominating and chlorinating oxidants during sepsis;Gaut;Proc. Natl. Acad. Sci. USA,2001

3. Molecular chlorine generated by the myeloperoxidase-hydrogen peroxide-chloride system of phagocytes produces 5-chlorocytosine in bacterial RNA;Henderson;J. Biol. Chem,1999