Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice-Reference-Cited by-同舟云学术

Phosphorylation of 4EBP by oral leucine administration was suppressed in the skeletal muscle of PGC-1α knockout mice

Published:2016-02-01 Issue:2 Volume:80 Page:288-290
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Yoshimura Ryoji¹²,Minami Kimiko¹,Matsuda Junichiro³,Sawada Naoki⁴⁵,Miura Shinji⁶,Kamei Yasutomi¹

Affiliation:

1. Graduate School of Life and Environmental Sciences, Kyoto Prefectural University, Kyoto, Japan

2. Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan

3. Laboratory of Animal Models for Human Diseases, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

4. Section of Cardiology, Department of Medicine, University of Chicago, Chicago, IL, USA

5. Global COE Program, Tokyo Medical and Dental University, Tokyo, Japan

6. Graduate School of Nutritional and Environmental Sciences, University of Shizuoka, Shizuoka, Japan

Abstract

Abstract Leucine is known to increase mTOR-mediated phosphorylation of 4EBP. In this study, leucine was administered to skeletal muscle-PGC-1α knockout mice. We observed attenuated 4EBP phosphorylation in the skeletal muscle, but not in the liver, of the PGC-1α knockout mice. These data suggest that skeletal muscle-PGC-1α is important for leucine-mediated mTOR activation and protein biosynthesis.

Funder

Council for Science, Technology and Innovation (CSTI),

Cross-ministerial Strategic Innovation Promotion Program (SIP),

Technologies for creating next-generation agriculture, forestry and fisheries” (funding agency: Bio-oriented Technology Research Advancement Institution, NARO).

Japan Association for the Advancement of Medical Equipment

The Michael Fund International Foundation for Genetics Research

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/80/2/288/36806839/bbb0288.pdf

Reference16 articles.

1. Regulation of protein synthesis by branched-chain amino acids in vivo;Yoshizawa;Biochem. Biophys. Res. Commun,2004

2. Differential dose response of mTOR signaling to oral administration of leucine in skeletal muscle and liver of rats;Yoshizawa;Biosci. Biotechnol. Biochem,2013

3. TOR signaling in growth and metabolism;Wullschleger;Cell,2006