Antiallergic activity of rosmarinic acid esters is modulated by hydrophobicity, and bulkiness of alkyl side chain-Reference-Cited by-同舟云学术

Antiallergic activity of rosmarinic acid esters is modulated by hydrophobicity, and bulkiness of alkyl side chain

Published:2015-07-03 Issue:7 Volume:79 Page:1178-1182
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Zhu Fengxian¹,Xu Zhongming²,Yonekura Lina¹³,Yang Ronghua²,Tamura Hirotoshi¹³

Affiliation:

1. The United Graduate School of Agricultural Sciences, Ehime University, Matsuyama, Japan

2. College of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, China

3. The Graduate School of Agriculture, Kagawa University, Miki-cho, Kagawa, Japan

Abstract

Abstract Methyl, propyl and hexyl esters of rosmarinic, caffeic and p-coumaric acids were tested for antiallergic activity, and rosmarinic acid propyl ester exhibited the greatest β-hexosaminidase release suppression (IC50, 23.7 μM). Quadratic correlations between pIC50 and cLogP (r2 = 0.94, 0.98, and 1.00, respectively) were observed in each acid ester series. The antiallergic activity is modulated by hydrophobicity, and alkyl chain bulkiness.

Funder

Monbukagakusho Scholarship (Ministry of Education, Culture, Sports, Science and Technology, Japan)

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/79/7/1178/36821501/bbb1178.pdf

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