Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε)-Reference-Cited by-同舟云学术

Pr-SNTX, a short-chain three-finger toxin from Papuan pigmy mulga snake, is an antagonist of muscle-type nicotinic acetylcholine receptor (α2βδε)

Published:2016-01-02 Issue:1 Volume:80 Page:158-161
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Yamauchi Yoko¹,Kimoto Hikari¹,Yang Xianyu²,Filkin Sergey³,Utkin Yuri³,Kubo Tai¹⁴,Inagaki Hidetoshi¹

Affiliation:

1. Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan

2. College of Animal Science and Biotechnology, Zhejiang A & F University, Lin’An, China

3. Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

4. United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan

Abstract

Abstract Three-finger toxins (3FTxs) are one of the major components in snake venoms. In this study, we isolated a cDNA encoding a short-chain 3FTx, Pr-SNTX, from Pseudechis rossignolii. The amino acid sequence of Pr-SNTX is nearly identical to that of its ortholog in Pseudechis australis. Pr-SNTX protein inhibited muscle-type (α2βδε), but not neuronal α7 nicotinic acetylcholine receptor (nAChR) activity.

Funder

Ministry of Education, Science, Sports, and Culture, Grant-in-Aid for Scientific Research (C),

Russian Foundation for Basic Research

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/80/1/158/36807392/bbb0158.pdf

Reference17 articles.

1. A guide to the snakes of Papua New Guinea;Shea,1996

2. Snakes across the Strait:trans-Torresian phylogeographic relationships in three genera of Australasian snakes (Serpentes:Elapidae:Acanthophis, Oxyuranus, and Pseudechis);Wüster;Mol. Phylogenet. Evol,2005

3. A new species of snake (Serpentes:Elapidae) from Irian Jaya;Hoser;Litt. Serpentium,2000

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