Anti-aging and anti-microbial effects of melleolide on various types of yeast-Reference-Cited by-同舟云学术

Anti-aging and anti-microbial effects of melleolide on various types of yeast

Published:2014-03-04 Issue:3 Volume:78 Page:455-457
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Nakaya Shigeru¹,Kobori Hajime²,Sekiya Atsushi³,Kawagishi Hirokazu²⁴,Ushimaru Takashi¹⁵

Affiliation:

1. Faculty of Science, Shizuoka University, Shizuoka, Japan

2. Graduate School of Science and Technology, Shizuoka University, Shizuoka, Japan

3. Kyushu Research Center, Forestry & Forest Products Research Institute, Kumamoto, Japan

4. Research Institute of Green Science and Technology, Shizuoka University, Shizuoka, Japan

5. Biological Science, Graduate School of Science, Shizuoka University, Shizuoka, Japan

Abstract

Abstract The chronological lifespan (CLS) of the budding yeast Saccharomyces cerevisiae is a model for the aging of post-mitotic cells in higher eukaryotes. In this study, we found that the sesquiterpene aryl ester melleolide expands the CLS of budding yeast. In contrast, melleolide compromised the CLS of the fission yeast Schizosaccharomyces pombe. This indicates that melleolide might have a potential anti-aging activity against some types of cell, and that it might be useful as a selective anti-fungal drug.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/78/3/455/36800399/bbb0455.pdf

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4. Melleolide, a new antibiotic from

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