Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner-Reference-Cited by-同舟云学术

Commensal bacteria directly suppress in vitro degranulation of mast cells in a MyD88-independent manner

Published:2014-10-03 Issue:10 Volume:78 Page:1669-1676
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kasakura Kazumi¹²³,Takahashi Kyoko¹,Itoh Tomoko¹,Hosono Akira¹,Momose Yoshika⁴,Itoh Kikuji⁴,Nishiyama Chiharu²³,Kaminogawa Shuichi¹

Affiliation:

1. College of Bioresource Sciences, Nihon University, Fujisawa, Japan

2. Atopy (Allergy) Research Center, Juntendo University School of Medicine, Tokyo, Japan

3. Department of Biological Science and Technology, Tokyo University of Science, Tokyo, Japan

4. Department of Veterinary Public Health, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan

Abstract

Abstract The intestine harbors a substantial number of commensal bacteria that provide considerable benefits to the host. Epidemiologic studies have identified associations between alterations in the composition of the intestinal microbiota and the development of allergic disease. However, the cellular and molecular mechanisms underlying these effects remain to be determined. Here, we show that heat-killed commensal bacteria suppressed degranulation of mast cells in vitro in a MyD88-independent manner. In particular, Enterococcus faecalis showed the strongest suppression of degranulation through partial inhibition of Ca2+ signaling upon the high affinity IgE receptor (FcεRI) cross-linking.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/78/10/1669/36798587/bbb1669.pdf

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