Syntheses and biological activities of the proposed structure of apteniol A and its derivatives-Reference-Cited by-同舟云学术

Syntheses and biological activities of the proposed structure of apteniol A and its derivatives

Published:2014-09-02 Issue:9 Volume:78 Page:1485-1489
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Nishikawa Hikaru¹,Noshita Toshiro²,Tai Akihiro²,Ouchi Hidekazu³,Okamoto Taisuke⁴,Saito Akiko⁴⁵,Yamada Teiko⁶,Iomori Atsuko¹,Ishimata Nao²

Affiliation:

1. Program in Biological System Sciences, Graduate School of Comprehensive Scientific Research, Prefectural University of Hiroshima, Shobara, Japan

2. Faculty of Life and Environmental Sciences, Department of Life Sciences, Prefectural University of Hiroshima, Shobara, Japan

3. Faculty of Pharmaceutical Education, Department of Pharmacy, Kinki University, Higashiosaka, Japan

4. Graduate School of Engineering, Osaka Electro-Communication University, Neyagawa, Japan

5. Faculty of Engineering, Department of Environmental Science, Osaka Electro-Communication University, Neyagawa, Japan

6. Department of Bioscience and Biotechnology for Future Bioindustry, Graduate School of Agricultural Science, Tohoku University, Sendai, Japan

Abstract

Abstract We describe the syntheses of the proposed structure of diphenyl ether oxyneolignan, apteniol A and its derivatives. The diphenyl ether moiety of proposed apteniol A was formed via Ullmann ether synthesis, but the spectral data of the synthesized apteniol A did not agree with that in previous studies. The dimethyl ester derivative of the proposed apteniol A was found to enhance neurite outgrowth in PC12 cells and inhibit antigen-induced degranulation in RBL-2H3 cells.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/78/9/1485/36799401/bbb1485.pdf

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2. The structure proposed for apteniol D is different from that of the compound obtained by total synthesis;Natural Product Research;2016-08-25

3. Synthesis and degranulation-inhibiting activities of the proposed apteniols B, C, and G;Bioscience, Biotechnology, and Biochemistry;2015-11-02