Bactericidal activity of nukacin ISK-1: an alternative mode of action-Reference-Cited by-同舟云学术

Bactericidal activity of nukacin ISK-1: an alternative mode of action

Published:2014-07-03 Issue:7 Volume:78 Page:1270-1273
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Roy Urmi¹,Islam Mohammad Riazul¹,Nagao Jun-ichi²,Iida Hiroshi³,Mahin Abdullah-Al¹,Li Mengqi¹,Zendo Takeshi¹,Nakayama Jiro¹,Sonomoto Kenji¹⁴

Affiliation:

1. Laboratory of Microbial Technology, Division of Applied Molecular Microbiology and Biomass Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan

2. Section of Infection Biology, Department of Functional Bioscience, Fukuoka Dental College, Fukuoka, Japan

3. Laboratory of Zoology, Division of Agricultural Bioresource Sciences, Department of Bioresource Sciences, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan

4. Laboratory of Functional Food Design, Department of Functional Metabolic Design, Bio-Architecture Center, Kyushu University, Fukuoka, Japan

Abstract

Abstract We previously reported bacteriostatic action of nukacin ISK-1 against Bacillus subtilis JCM 1465T. Here, we found its bactericidal activity against Micrococcus luteus DSM 1790 and Staphylococcus simulans 22, showing decrease in cell viability, cell lysis, and dissipation of the membrane potential. Moreover, leakage of small molecules such as K+, suggested the formation of small-sized or specific K+-conducting-pores by nukacin ISK-1.

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/78/7/1270/36796027/bbb1270.pdf

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