Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity-Reference-Cited by-同舟云学术

Inhibition of malaria parasite growth by quinomycin A and its derivatives through DNA-intercalating activity

Published:2015-04-03 Issue:4 Volume:79 Page:633-635
ISSN:0916-8451
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Hayase Hiroki¹,Watanabe Nobumoto¹²³,Lim Chung Liang¹³,Nogawa Toshihiko²,Komatsuya Keisuke⁴,Kita Kiyoshi⁴,Osada Hiroyuki¹²³

Affiliation:

1. Antibiotics Laboratory, RIKEN, Wako, Japan

2. Chemical Biology Research Group, RIKEN Center for Sustainable Resource Science, Wako, Japan

3. Industrial Biotechnology Research Laboratory, School of Biological Sciences, Universiti Sains Malaysia, Penang, Malaysia

4. Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan

Abstract

Abstract Quinomycin A and its derivatives were identified as potent antimalarial (Plasmodium falciparum) agents in a screen of the RIKEN NPDepo chemical library. IC50 values of quinomycin A and UK-63,598 were approximately 100 times lower than that of the antimalarial drug chloroquine. This activity was mitigated by the addition of plasmid DNA, suggesting that these compounds act against parasites by intercalating into their DNA.

Funder

This work was supported in part by “Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science, and Technology of Japan” and “Science and Technology Research Promotion Program for Agriculture, Forestry, Fisheries and Food Industry.”

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/79/4/633/36806757/bbb0633.pdf

Reference14 articles.

1. Spread and evolution of Plasmodium falciparum drug resistance;Mita;Parasitol Int,2009

2. Construction of a microbial natural product library for chemical biology studies;Kato;Curr. Opin. Chem. Biol,2012

3. Human malaria parasites in continuous culture;Trager;Science,1976

4. Synergy of ferrous ion on 5-aminolevulinic acid-mediated growth inhibition of Plasmodium falciparum;Komatsuya;J. Biochem,2013

5. Thousands of chemical starting points for antimalarial lead identification;Gamo;Nature,2010

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