Anti-stress effects of rosemary (Rosmarinus officinalis L.) leaf extract on intestinal goblet cells and immobility of forced-swimming test in BALB/c mice-Reference-Cited by-同舟云学术

Anti-stress effects of rosemary (Rosmarinus officinalis L.) leaf extract on intestinal goblet cells and immobility of forced-swimming test in BALB/c mice

Published:2020-11-01 Issue:11 Volume:84 Page:2385-2389
ISSN:1347-6947
Container-title:Bioscience, Biotechnology, and Biochemistry
language:en
Short-container-title:

Author:

Kayashima Tomoko¹,Nagao Koji²,Umino Mituki³,Kaikiri Hiroko⁴,Shibata Sachi⁵,Matsubara Kiminori³⁶

Affiliation:

1. Department of School Education Course, Faculty of Education, Saga University, Saga, Japan

2. Department of Biological Resource Science, Applied Biochemistry and Food Science Course, Faculty of Agriculture, Saga University, Saga, Japan

3. Department of Human Life Sciences Education, Graduate School of Education, Hiroshima University, Hiroshima, Japan

4. Department of Community Human Life, Hiroshima Bunka Gakuen Two-Year College, Hiroshima, Japan

5. Department of Pharmacy and Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Fukuyama University, Hiroshima, Japan

6. Division of Human Life Sciences Education, Graduate School of Humanities and Social Sciences, Hiroshima University, Hiroshima, Japan

Abstract

Abstract We investigated the anti-stress effect of rosemary (Rosmarinus officinalis L.) leaf extract (RLE) on restraint-stressed mice and found that RLE alleviated decreases in the number of intestinal goblet cells and amount of hepatic triglycerides. It also decreased the immobility time in the forced-swimming test and activation of microglia in the brain, suggesting that RLE has beneficial effects on stress-induced dysfunctions.

Funder

JSPS KAKENHI

Japan Society for the Promotion of Science

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Link

http://academic.oup.com/bbb/article-pdf/84/11/2385/36834976/bbb2385.pdf

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